Disorderly conduct and disturbing the peace: how loss of cell polarity and tissue architecture drives cancer progression

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1079133

Funding Status
Closed

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Funded Activity Summary

Disorganisation of cells within tumours is a defining feature of aggressive cancers. Using mouse models and 3D organ cultures we have now shown that disruption of a family of organising genes found in every cell confuses the arrangement, orientation and connection of cells within an organ thus causing tumours. Here we will provide a new understanding of how the disorganisation of cells in human tissue leads to cancer and develop new cancer therapeutic approaches to keep tissues well-organised.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2019

Funding Scheme: Research Fellowships

Funding Amount: $638,517.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer biology | cell polarity | mouse models | signalling pathways | therapeutic target

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