Cleavage methods of mutation detection: Improvement and application in cardiovascular disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/107800

Funding Status
Closed

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Funded Activity Summary

Genes contain the information to build our body and keep it operating normally. These genes are inherited from our parents and number around 100,000. Faults in these genes can cause inherited diseases such as cystic fibrosis, cancers and common disorders such as Asthma and diabetes. These genes need detecting so that particular genes can be identified as causing the disease and also so that patients can have their disease properly diagnosed so that proper therapy and information can be given to the patients. In future similar changes (but changes not causing disease) may be searched for in patients to overcome the side effects of drugs. Our centre specializes in the methods of detecting faults and their application. Two of our methods are being used around the world and one is being sold as simple kit. These methods still have drawbacks and the work proposed is to overcome some of these. We propose to apply our and other methods to faults in genes which have recently been shown to cause diseases of the artery. This is an exciting new development that shows that this disease is similar to cancer. We are fortunate to have attracted Dr Paula Bray from the laboratory which discovered this. This new finding needs to be studied in more detail and may identify life-style factors which cause coronary heart disease. Our studies will also assist in gene therapy when it becomes available.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $1,044,349.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetics Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

A simple test for a common mutation in TGF-betaRII | Cardiovascular disease | DNA diagnostics | Gene analysis in carotid artery restenosis | Mutation Detection Techniques | Mutation scanning methods avoiding electrophoresis | Restenosis | TGF-betaBI receptor II mutations

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