Investigation of regulators that control the pro-survival molecule MCL1 and its stabililty in lymphoma and myeloma cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1075151

Funding Status
Closed

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Funded Activity Summary

B cell malignancies are common and in many cases result in mortality. The BCL-2 family protein MCL-1 has been shown to be over-expressed in many B cell malignancies. However, the regulation and biology of MCL-1 in these cancers remains largely unknown. We aim to define mechanisms that control regulation of MCL-1 expression in cancer cells at the transcriptional and protein level and hence identify new therapeutic targets.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: Postgraduate Scholarships

Funding Amount: $169,162.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Tumour Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer biology | cancer immunology | haematological malignancy | haematology | immunology

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