Interactions between aberrant transcriptional programs and methylation in primary myelodysplasia and leukaemia.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1073768

Funding Status
Closed

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Funded Activity Summary

Impaired development of blood stem cells leads to haematological disease such as leukaemia. State of the art next-generation sequencing and bioinformatics identified molecular pathways essential for normal blood development and a core set of these genes repressed in leukaemia. Understanding the mechanism by which these genes are re-activated by the non-specific drug azacitidine contributes to the development of new therapeutics with increased efficiency and reduced side effects.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $316,449.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Bioinformatics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bioinformatics | haematological malignancy | haematopoietic stem cells | systems biology | transcriptional regulation

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