Interactions between Herpes simplex viral and neuronal motor proteins

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/107374

Funding Status
Closed

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Funded Activity Summary

Herpes simplex virus (HSV) lies dormant within the nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported down the nerve to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this grant is to determine how Herpes Simplex virus is transported within nerve cells at the molecular level. It builds on recent discoveries of a direct interaction between a Herpes simplex viral protein and the nerve cell motor protein which transports essential components down nerves from the spinal cord to the skin. Ultimately we aim to develop inhibitors of this process which might be candidates for further development as antivirals for control of recurrent herpes simplex.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $222,962.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antivirals for Herpes simplex | Dorsal root ganglia | Genital Herpes | Herpes labialis | Herpes simplex encephalitis | Herpes simplex virus | Kinesin | Neurones

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