Molecular Pharmacology and Physiology of Glycine Transport

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/107332

Funding Status
Closed

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Funded Activity Summary

The simple amino acid glycine plays an important role in many metabolic events in the body and in the mammalian central nervous system glycine has additional functions as a neurotransmitter. In the spinal cord and brain stem, glycine acts as an inhibitory neurotransmitter through activation of glycine receptors. In the brain, glycine may also act as an excitatory neurotransmitter through its action as a co-activator with glutamate at the NMDA subtype of glutamate receptors. This project will address the issue as to whether glycine transporters have the capacity to regulate glycine concentrations within excitatory synapses and thereby play an active role in regulating neurotransmission. This work will form the basis for understanding the role that glycine plays in normal brain functions, such as learning and memory, and also under pathological conditions following a stroke. This work will also serve as a basis for assessing the therapeutic potential of manipulating glycine concentrations in the treatment of neurological disorders, such as schizophrenia.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $170,274.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

electrophysiology | glycine transporters | learning and memory | membrane proteins | molecular biology | neurochemistry | schizophrenia | stroke

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