Interactions between developmental NMDA receptor dysfunction, genetic vulnerability and early-life stress in schizophrenia: studies of dysbindin mutant mice and living individuals at high risk of schizophrenia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1072878

Funding Status
Closed

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Funded Activity Summary

This project will investigate two key pathways implicated in schizophrenia: glutamatergic (excitatory) neurotransmission and stress signalling. We will study how glutamatergic deficits emerge across postnatal development, in the presence or absence of early-life stress, in a schizophrenia-relevant mouse model, and investigate the interactions between stress and glutamatergic deficits in neuroepithelial cells from living individuals at high risk of schizophrenia.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $347,457.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

developmental biology | glutamate receptors | mouse models | schizophrenia | stress

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