MATERNAL UNDERNUTRITION, INFANT REFEEDING, ADIPOSITY AND DIABETES

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/107261

Funding Status
Closed

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Funded Activity Summary

Malnutrition is a major health problem throughout the world and one of the priority areas for the WHO. Refeeding program guidelines have been established and implemented when children are assessed as being malnourished. Recent studies on the effect of these important programs throughout the world have suggested they may not have been as successful as wished. Indeed, even though many of the subjects are the urban poor, it has been found that many are developing diabetes in their twenties. This is associated with an increase in abdominal fatness, out of proportion to the rest of the body's size and shape. The increase in diabetes in this group is most worrying and a major public health problem. It is not known whether the diabetes and abdominal fatness are caused by the refeeding programs or whether they are due to the fact that the body's metabolism was programmed during pregnancy. Perhaps the infants were malnourished whilst they were developing during pregnancy and metabolism was changed so they could store fat easily and not use glucose as readily in the rest of the body. This study is designed to show whether there are metabolic changes which predispose to diabetes and fatness present at birth in those who are malnourished or whether the refeeeding program designed to help them grow is the cause of these later problems.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $297,323.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrition And Dietetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Altered expression of enymes and transportes in malnutrition | Diabetes and Insulin resistance | Dietary intake | Effect of maternal undernutrition on fetal metabolism | Effect of refeeding protein on adipocyte metabolism | Maternal and fetal undernutrition | Muscle insulin resistance | Refeeding after Malnutrition | Undernutrition and lipogenesis in abdominal adipocytes

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