To determine whether Myc-driven transformation in haematopoietic cell lineages is dependent on high-levels of Myc protein expression.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1072477

Funding Status
Closed

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Funded Activity Summary

Myc is an essential cellular protein but is also a common drive of cancer in multiple tissues. In blood cancers Myc is frequently overexpressed. In contrast, Myc is rarely overexpressed in early stage solid cancers, although often elevated levels at later stages. We will employ unique models of cancer in which Myc can be activated at different set levels at different times during blood cell development to address what the specific contributions of different levels of Myc are in the evolution of blood cancers.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2019

Funding Scheme: Early Career Fellowships

Funding Amount: $371,896.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

c-myc | haematological malignancy | mouse models | oncogenes | transcriptional regulation

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