Investigation of small molecule interactions with the human leukocyte antigen and their role in non-infectious disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1072159

Funding Status
Closed

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Funded Activity Summary

The Human Leukocyte Antigens (HLA) play a key role in the immune system helping the body differentiate healthy from diseased cells. Numerous autoimmune diseases and adverse drug reactions are associated with specific HLA variants. This study seeks to unlock the mechanisms behind these diseases, investigating how small molecules including drugs interact with the HLA to make healthy body cells seem foreign. This research has the potential to inform strategies for disease avoidance and management.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $316,449.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell activation | adverse drug reactions | antigen presentation | antigen processing | autoimmunity | human leukocyte antigen (HLA) | hypersensitivity | mass spectrometry

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