Oligomers of the Alzheimer's amyloid-? peptide: structure, mechanism of toxicity and small molecule interactions

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1071985

Funding Status
Closed

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Funded Activity Summary

Alzheimer’s disease is a devastating neurodegenerative disease that currently affects 240 000 Australians. The protein called amyloid-? is found in deposits in the brains of Alzheimer’s patients. The toxic form of this protein is thought to be small aggregated particles called ‘oligomers’. This work aims to investigate the structure of these particles, the reason why they are toxic, as well as their interaction with the neuroprotective compound EGCG, which is found in green tea.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2020

Funding Scheme: Early Career Fellowships

Funding Amount: $356,324.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

amyloid | biophysics | nuclear magnetic resonance (NMR) spectroscopy | protein aggregation | protein complexes | protein folding | protein function | protein structure | structural biology

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