Investigating the cellular requirement for STIM1 phosphorylation and store-operated calcium entry suppression during mitosis: roles in development and cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1071074

Funding Status
Closed

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Funded Activity Summary

Cells are constantly interacting with and modifying their surrounding environment. The intracellular calcium signal is one mechanism cells use to translate signals from the microenvironment into cellular responses. This proposal seeks to explore why a key calcium signalling pathway, known as store-operated calcium entry, is specifically silenced during cell division, and to determine how reversing this inhibition affects cell division during normal development and in cancer.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: Early Career Fellowships

Funding Amount: $344,900.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

breast cancer | breast development | calcium channels | calcium signalling | cancer biology | cell division | microenvironment

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