Insights into the epitranscriptome: linking RNA methylation and intellectual disability

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1070631

Funding Status
Closed

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Funded Activity Summary

The string of nucleotides in an RNA molecule can contain the information to make proteins or to regulate diverse biological processes. Chemical modifications can be added to certain nucleotides that impact the regulation, structure or function of RNA. Recently, mutations in enzymes that modify RNA have been found in patients with intellectual disability. This project focuses on identifying and characterising specific RNA modification sites in brain that when disrupted cause mental retardation.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $426,878.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA | RNA processing | cognitive dysfunction | epigenetics | gene regulation | gene-environment interaction | hippocampus | intellectual disability | mouse models

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