Repair of epigenetic abnormalities in human induced pluripotent stem cells by targeted epigenome engineering

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1069830

Funding Status
Closed

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Funded Activity Summary

New advances enable a patient’s cells to be reprogrammed into an adult stem cell, with the capacity to turn into any specialized cell type to replace a patient’s damaged cells. However, we have discovered that adult stem cells are flawed, they have an epigenetic memory of their past specialized form that limits their capacity to transform into other specialized cells. We will use a novel molecular tool to erase this memory, thus repairing adult stem cells for their use in regenerative medicine.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $810,366.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA methylation | adult stem cells | epigenetics | genomics | regenerative medicine

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