RNA-based Expanded Repeat Pathogenic Pathway in Neurodegenerative Diseases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1069348

Funding Status
Closed

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Funded Activity Summary

Many important human genetic diseases (incl Huntington’s Disease) are due to a common mutation mechanism with some similarities in clinical outcome (late in life nerve cell loss). For these diseases it is still not known what mechanism is responsible for causing the disease. This is essential in order to delay onset, slow progression or effect cure. We will test a mechanism for disease pathology that we have identified in a simple model organism and seen evidence of its activity in human disease

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $595,153.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurogenetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Huntington's disease | RNA processing | Toll-like receptors | ataxia | autosomal dominant disorder | dynamic mutation | frontotemporal dementia | neurodegeneration | neuroinflammation | trinucleotide repeat disorder

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