The coronary vascular bed, shear stress, endothelial signalling and myocyte electrophysiology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/106930

Funding Status
Closed

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Funded Activity Summary

Physiologic control muscle performance includes a little understood signal from the walls of blood vessels stimulated by pressure and flow which effect muscle function. How this signal operates is controversial. We have developed a model which enables the evaluation of such signalling where changes in flow in the circumflex coronary artery induce easily measured local changes in electrophysiology which are confined to the territory of the circumflex coronary artery and which can be compared with control values from the left anterior descending coronary artery territory. We propose to use this stable model to evaluate the origin, the transmission agent and the mechanism by which it alters the action potential duration.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $133,774.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical molecular engineering of nucleic acids and proteins

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Coronary artery disease | Coronary artery flow | Hypertension | Insulin Resistance | Myocyte action potential duration | Shear stress and endothelial signals

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