The role of past sun exposure, infection history and other exogenous factors in Multiple Sclerosis

Funded Activity Summary

Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the brain and spinal cord that leads to various degrees of disability. The causes of MS are not yet known, and there is presently no cure. However, there is strong evidence that both an inherited susceptibility and environmental factors are important. This environmental case control study will be conducted in Tasmania and will run concurrent to a genetic project on MS which allows assessment of gene-environment interactions. It focuses on infections, timing of childhood infections and long term sun exposure. It has been suggested that MS may be due to an immune disturbance following viral infection and that the timing of childhood infections may be initially important. Also, in Australia, there is a sevenfold increase in MS prevalence as one moves from Queensland to Tasmania. This latitudinal gradient might be due to ultra violet radiation, through an influence on immune function. Beside those main focuses, the study will include other environmental factors like chemicals, diet and vaccinations. Hopefully this project will contribute to a better understanding of the causes of MS, which are relevant for preventative strategies and devising optimal treatment.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2001

Funding Scheme: NHMRC Project Grants

Funding Amount: $92,011.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Optical technology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

case control | childhood exposures | childhood infection | disease aetiology | environment | multiple sclerosis | past UV radiation exposure | population-based | ultraviolet radiation

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