Genetic validation of Stat3 as a tractable pharmacological target in gastrointestinal disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1069024

Funding Status
Closed

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Funded Activity Summary

Cancers of the stomach and the colon are a major health burden. One of the central signaling molecules that drives these cancers is called Stat3. Here we propose to use a novel strain of mice that allows us to experimentally dial down the amount of Stat3 protein and hence to predict how effective a future anti-Stat3 cancer drug will be.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $586,964.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

animal model | cytokines | gastrointestinal disease | gastrointestinal tumourigenesis | signalling pathways

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