A mechanistic approach to therapy development for chronic traumatic encephalopathy using small and large animal models of concussion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1068712

Funding Status
Closed

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Funded Activity Summary

Repeated concussion in athletes has recently been associated with the development of a neurodegenerative disorder known as chronic traumatic encephalopathy (CTE). While the neuropathology seems to be well characterised, the mechanisms associated with CTE development are not. This proposal will demonstrate that mechanically induced release of the neurotransmitter substance P accounts for much of the neuropathology in CTE, and will develop a novel therapy that will prevent such development.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $492,844.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

concussion | encephalopathy | neurodegeneration | substance P | traumatic brain injury (TBI)

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