Understanding age-related protein aggregation. The mechanism of cataract and its prevention

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1068087

Funding Status
Closed

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Funded Activity Summary

Cataract arises from clouding of the eye lens due to the aggregation of crystallin proteins whose high concentration and close packing facilitate lens transparency. This proposal will investigate crystallin structure and interactions to understand the reasons for cataract formation and its prevention via the design of aggregation inhibitors. The results will facilitate the development of drugs to prevent cataract and other related protein aggregation diseases, e.g. Alzheimer’s and Parkinson’s.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $709,333.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cataract | drug design | drug targeting | neurological diseases | protein aggregation | protein characterisation | protein chemistry | protein conformation | protein modification | protein-protein interaction

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