The role of accessory subunits and assembly factors in the biogenesis of respiratory chain complex I

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1068056

Funding Status
Closed

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Funded Activity Summary

The mitochondrial respiratory chain produces most of the energy required for our cells to grow and function. Complex I is the first enzyme of this chain and its defects are the most prevalent cause of mitochondrial disease, which often results in infant fatality. Defects in complex I have also been associated with Parkinson's disease and oxidative stress. This study will provide important new information into how complex I is built and what goes wrong to cause disease.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $569,987.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

gene disruption | mitochondrial disease | mitochondrial function | protein complexes | respiratory chain

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