A three-tiered strategy to prevent destabilisation of the induced pluripotent stem cell genome by L1 retrotransposition

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1067983

Funding Status
Closed

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Funded Activity Summary

Retrotransposons are mobile genes that copy-and-paste themselves in our genome. Previously thought to represent “junk DNA”, retrotransposons are increasingly recognised to play major roles in biology. In recent publications in Cell and Nature, we found that retrotransposons move in mature human cells. In the current study, we will determine whether the same activity occurs when these cells are reprogrammed to become stem cells, possibly impacting stem cell based therapies.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $708,707.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Regenerative Medicine (incl. Stem Cells and Tissue Engineering)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

epigenetics | genomics | sequencing | stem cell biology | transposons

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