Chemical biology investigation of cell death processes: development of molecular probes interfering with necroptosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1067289

Funding Status
Closed

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Funded Activity Summary

Necroptotic programmed cell death has a key role in maintaining healthy tissue, and dysregulation of this process is associated with the pathology of infection and a range of chronic inflammation diseases for which there are few satisfactory treatments. In this project, we will discover small, drug like, molecules that interfere with the necroptosis pathway. These small molecules have the potential to become new therapeutics to treat these inflammatory diseases and will be invaluable probes to study this key biological pathway.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $630,736.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell death | inflammatory arthritis | inflammatory bowel disease (IBD) | kinase inhibitors | kinases | medicinal chemistry | necrosis | signal transduction

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