Non-coding RNA regulation of virulence in enterohaemorrhagic E. coli

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1067241

Funding Status
Closed

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Funded Activity Summary

Shiga toxins cause potentially fatal haemolytic uremic syndrome (HUS) and are transferred between bacterial pathogens by bacteriophage (bacterial viruses). We have recently found that the Shiga toxin encoding bacteriophage encodes an unusually large number of non-coding RNAs (RNA regulators of gene expression). This Project aims to understand how these RNA regulators benefit the Shiga toxin bacteriophage and use this knowledge to develop interventions that will prevent expression of the toxin.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $389,313.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA | RNA binding proteins | bacterial evolution | bacterial pathogenicity | bacterial virulence factors | gene regulation | gene transcription | molecular genetics | molecular microbiology | sequencing

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