The dengue virus glycoprotein NS1 binds cholesterol and mediates cellular activation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1067226

Funding Status
Closed

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Funded Activity Summary

Cholesterol has been shown to play a vital role in the life cycle of many viruses. This project will investigate the basis of dengue virus interaction with this important host molecule and along with investigations of how dengue is able to stimulate host cells, will provide new insights into the way these viruses cause severe disease. Findings from this study will also aid in the development of new drug strategies for dengue and related viruses such as West Nile virus.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $632,029.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell activation | cholesterol | cytokine production | dengue virus | secretory pathway

Related Links