The role of C-reactive protein (CRP) in localising inflammation to misfolded proteins and “stressed” cells: A basis for the development of new anti-inflammatory reagents?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1067214

Funding Status
Closed

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Funded Activity Summary

Many diseases are exacerbated by inflammatory reactions. We describe how a protein circulating in the blood is a major driver of inflammatory reactions and how it is transformed from an inactive state to an active, highly pro-inflammatory state. Our project aims to understand how this transformation occurs at the molecular level, and to develop diagnostic techniques and innovative drugs to treat diseases such as heart attack, Alzheimer’s disease and other inflammatory diseases.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $723,488.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of Biological Macromolecules

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | anti-inflammatory agents | drug development | inflammation | modelling | myocardial infarction | myocardial reperfusion injury

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