Understanding intrinsic and acquired resistance to anti-FGFR therapies

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1067140

Funding Status
Closed

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Funded Activity Summary

In vitro and in vivo preclinical data suggests that inhibition of FGFR in endometrial cancer patients may be a viable therapeutic approach. Data from other cancers suggests that despite remarkable initial responses to kinase inhibitors, cancer cells eventually develop resistance. This project aims to identify and characterize the mechanisms of resistance that emerge following FGFR inhibition in order to design combination therapies that may delay and/or prevent the emergence of resistance.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $797,051.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Molecular Targets

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

endometrial cancer | fibroblast growth factor receptors (FGFR) | inhibition | mechanisms | receptor tyrosine kinase (RTK) | resistance

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