Characterisation and modelling of schizophrenia-associated dysregulation of miR-137 expression

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1067137

Funding Status
Closed

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Funded Activity Summary

We have identified mutation-associated changes in the expression of a non-coding microRNA gene in the cerebral cortex in schizophrenia. This gene, known as MIR137, functions by repressing hundreds of target genes and therefore has major implications for schizophrenia. The project will identify the genetic mechanism affecting the expression of MIR137, and determine the biological and behavioural implications of this change in the context of schizophrenia.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $581,661.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bioinformatics | gene expression | gene regulation | gene silencing | genetic association | mental health | microrna | psychiatry | schizophrenia and related disorders | therapeutic target

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