Identification of a novel adhesion mechanism regulating platelet-endothelial interactions.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1066957

Funding Status
Closed

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Funded Activity Summary

Platelets are important blood cells, stopping bleeding in the event of blood vessel injury. However, platelets can also interact with the blood vessel lining (endothelium) to regulate and in some cases promote inflammation. We have identified a new structure platelets use to stick to endothelium, which under disease states (enhanced oxidative stress), can promote inflammation. We will investigate how tractopods form, and examine their role in the setting of elevated oxidative stress and inflammatory disease.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $501,691.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

endothelial dysfunction | oxidative stress | platelet activation | platelet adhesion | platelet function

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