Investigating a novel role for the haemopoietic growth factor receptor, c-Mpl, in regulating shear-dependent platelet adhesive function

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1066956

Funding Status
Closed

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Funded Activity Summary

Platelets play a critical role in blood clot formation, with low platelet numbers leading to bleeding while excessive clot formation can cause heart attack and stroke. Platelets must ‘stick’ to injured blood vessels under blood flow (shear). We have discovered that the growth factor, c-Mpl, can regulate shear-dependent platelet sticking by controlling receptor ‘shedding’ from the cell surface. We will investigate how c-Mpl performs this new role, and examine platelet function in patients with myeloproliferative disease who have reduced c-Mpl.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $570,294.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

haemostasis | platelet adhesion | platelet function | receptor regulation | shear stress | thrombosis

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