Activating transcription factor 3 and cancer progression

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1066665

Funding Status
Closed

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Funded Activity Summary

We have shown that the transcription factor ATF3 suppresses bladder cancer spread. Turning off ATF3 is associated with disease progression in bladder and colorectal cancer. We will test whether levels of ATF3 can be used as a prognostic maker for disease progression, investigate the mechanisms underlying the actions of ATF3 in bladder and colorectal cancer and test whether therapeutically activating ATF3 can inhibit cancer progression.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $767,794.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bladder cancer | cancer progression | cancer therapy | colon cancer | innate immunity | molecular mechanisms | therapeutic agents | transcription factor | transgenic model | tumour suppression

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