Improving muscular dystrophy by targeting the ADAMTS5 metalloproteinase

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1066430

Funding Status
Closed

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Funded Activity Summary

Muscular dystrophy is a devastating childhood disorder. There is no cure and no effective therapy to stop the disease progressing to early death. Our pilot data show that muscular dystrophy in a mouse model is dramatically improved when the Adamts5 gene is inactivated. ADAMTS5 is an enzyme that remodels the extracellular matrix around cells. This suggests that inhibiting ADAMTS5 may be a new way to treat muscular dystrophy. We will test this idea in mice with muscular dystrophy

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $658,571.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

expression profiling | extracellular matrix | metalloproteinase | mouse models | muscular dystrophy | protein characterisation

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