Investigating mechanisms of axonal pathology following oligodendrocyte apoptosis: avenues for neuroprotection in early MS

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1066199

Funding Status
Closed

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Funded Activity Summary

Recent research suggests that Multiple Sclerosis could first be triggered by the death of a type of brain cell called an oligodendrocyte. These cells insulate nerve cells in the brain which help them function normally. We will test the idea that death of oligodendrocytes impairs nerve cell function by causing inflammation and by depriving nerve cells of energy. We will determine whether preventing inflammation and feeding the nerve cells an alternative source of energy can restore normal function.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $678,138.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

axonal degeneration | innate immunity | microglia | myelin | oligodendrocytes

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