Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1066069

Funding Status
Closed

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Funded Activity Summary

When blood glucose levels are high, insulin signals to fat and muscle cells to remove glucose from the blood. The uptake of glucose relies on membrane fusion events that deliver a specific glucose transporter protein to the cell surface in response to insulin signals. This process is affected in Type II diabetes. Our research will characterise the regulation of these membrane fusion events and will be important for understanding how insulin signals are communicated in health and disease.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $601,008.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

conformational change | exocytosis | membrane trafficking | protein complexes | vesicle trafficking

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