The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1065884

Funding Status
Closed

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Funded Activity Summary

Using mice with mutant genes causing amyotrophic lateral sclerosis, we will test whether motor neuron hyper-excitability during early development causes excessive synapse and dendrite formation, ultimately leading to neuronal death. We will also test whether activity-dependent secretion of neurotrophic factors and activation of their receptors plays a role in this disease. This will show whether neuronal hyper-activity and neurotrophic factor signaling plays a causal role in this disease.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $700,331.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Trk B | ephrin | motor neuron disease (MND) | neurophysiology | neurotrophic factors | synaptic plasticity

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