Modifying Brain Excitabilty by Upregulating the KCC2 Chloride Transporter

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1065882

Funding Status
Closed

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Funded Activity Summary

Brain activity depends upon the fine balance between neuronal excitation and inhibition. When this balance is lost, debilitating seizures can result, such as occurs in epilepsy. We have developed a new gene manipulation approach to enhance neuronal inhibition and prevent seizures in mice. We will examine the physiological mechanisms underlying this effect, and we propose that we can also use this genetic switch to stop the progression into epilepsy that occurs following a brain trauma.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $535,662.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

electrophysiology | gamma-aminobutyric acid (GABA) | membrane transport | neuroscience | seizures | synaptic mechanisms

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