Mechanisms responsible for neurogenic hypertension: Role of a novel interaction between amygdala-hypothalamic GABA pathways and the microRNA regulation of renin

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1065714

Funding Status
Closed

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Funded Activity Summary

We identified that mice bred to have high blood pressure (hypertension) have an overactive nervous system due to a faulty molecule in a small region of the brain that controls emotion and the response to stress. The high nervous activity affects a hormone in the kidney that may lead to hypertension. The proposal will determine the mechanisms and neurochemicals in the brain that are responsible for magnifying the responses to stress leading to hypertension and test a new therapy to treat high blood pressure.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $576,538.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA | amygdala | hypertension | hypothalamus | kidney | receptors | stress response | sympathetic nervous system

Related Links

ACN 633 798 857