Understanding the physiological consequences of biased signalling mediated by the glucagon-like peptide-1 receptor

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1065410

Funding Status
Closed

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Funded Activity Summary

The glucagon-like peptide 1 receptor is a major target for treatment of Type 2 diabetes and obesity. However, the development of drugs targeting this receptor is challenging as activation by different ligands can result in distinct signalling biases, a paradigm for which there is limited understanding of the physiological consequences. This project will address this critical knowledge gap and may allow for development of novel drugs with improved therapeutic outcomes.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $636,508.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

diabetes mellitus | insulin secretion | receptor dimerisation | receptors | signalling pathways

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