Defining the role of zinc in human macrophage responses to Salmonella

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1065391

Funding Status
Closed

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Funded Activity Summary

It is estimated that one third of the worlds population is affected by mild to moderate zinc deficiency, and that this predisposes to a range of infectious diseases. The immunomodulatory effects of zinc have been appreciated for many years, and indeed zinc supplementation is used to treat severe diarrhoeal diseases. This project aims to understand the anti-infective mechanisms of zinc by focusing on macrophages, a key cell type involved in killing invading microorganisms.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $592,049.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Salmonella typhimurium | Toll-like receptors | bacterial gastroenteritis | bacterial pathogen | gene expression | gene function | ion transport | macrophages | zinc deficiency | zinc supplementation

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