Impact of islet beta cell heparan sulfate in Type 2 diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1065068

Funding Status
Closed

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Funded Activity Summary

Type 2 diabetes (T2D) is a chronic metabolic disease which ultimately leads to the death of insulin-producing islet beta cells, elevated blood sugar levels and daily insulin injections. Since beta cells require the complex sugar heparan sulfate (HS) for survival, we will investigate whether beta cell failure in T2D results from defective HS production. HS replacement will be evaluated as a new therapeutic strategy for preserving beta cell function and preventing the need for insulin injections.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $576,777.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

heparan sulfate | heparanase | oxidative stress | proteoglycans | type 2 diabetes mellitus (non-insulin dependent diabetes mellitus)

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