Identifying the mechanism of the G2 phase UV checkpoint and repair response commonly defective in melanoma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1064807

Funding Status
Closed

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Funded Activity Summary

The UV component of sunlight is the major environmental factor driving the development of melanoma. UV radiation can directly mutate genes resulting in their inability to perform normal functions which may contribute to cancer. Despite the high number of mutations directly attributable to UV radiation, the mechanisms known to repair these mutations are generally normal in melanoma. This research will investigate a repair mechanism we have identified that is commonly defective in melanomas.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $569,656.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA repair | cell cycle regulation | melanoma | mutation analysis | skin cancer | ultraviolet (UV) irradiation

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