In vivo and biochemical appraisal of mitochondrial STAT3

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1063914

Funding Status
Closed

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Funded Activity Summary

The Signal Transducer and activator of transcription 3 (STAT3) protein is over-expressed or activated in most cancers. The paradigm for STAT3's role in cancer is that it drives the expression of genes which support tumour growth. Recently I found that STAT3 controls the altered metabolic state required for cancer progression, both by control gene expression and by entering the mitochondria. I propose define the mechanism of STAT3 mitochondrial activity and then translate these findings into animal models of cancer.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Career Development Fellowships

Funding Amount: $421,747.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

JAK/STAT pathway | leukaemia | metabolism | mitochondria | protein localisation

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