The role of UPF3B and nonsense mediated mRNA decay surveillance in the pathology of intellectual disability.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1063808

Funding Status
Closed

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Funded Activity Summary

Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundamental importance.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $789,954.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurogenetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA | autism spectrum disorders | expression profiling | gene expression | gene function | gene identification | intellectual disability | neurogenetics

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