How the intracellular pathogen Coxiella burnetii manipulates host small GTPases to facilitate disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1063646

Funding Status
Closed

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Funded Activity Summary

This study explores how the bacterium Coxiella burnetii causes the serious infectious disease Q fever. Coxiella is a potential biological weapon because it is stable in the environment and few organisms are required to cause disease. Coxiella is able to manipulate human cells to replicate in a unique location within the cell but little is known about how they do this. Here we will study the host proteins that are important during infection and how Coxiella manipulates these factors to facilitate intracellular replication.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $534,510.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Coxiella burnetii | GTPase | Q fever | gene silencing | intracellular bacterial infections | lysosome biology | molecular pathogenesis | pathogenic mechanisms | vesicle trafficking | virulence factors

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