An investigation into the molecular basis of MAIT cell recognition of vitamin B based metabolites

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1063587

Funding Status
Closed

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Funded Activity Summary

Mucosal associated invariant T cells (MAIT cells) are an abundant T-cell population in humans, that is found mostly in the gastrointestinal mucosa. We have recently shown that MAIT cells can be activated by metabolites of vitamin B. This proposal will investigate how the MAIT cells "see" vitamin B metabolites. This research will pave the way for novel therapeutics that can modulate MAIT cell activity.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $883,762.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

folic acid | immunity | microbial infections | mucosal immunity | structural immunology

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