Targeting the EGFR and c-Met Tyrosine Kinase Receptors in Myeloproliferative Neoplasms

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1063443

Funding Status
Closed

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Funded Activity Summary

We propose that in the blood disorders called Myeloproliferative Neoplasms (MPN) there are important changes that affect the function of receptors expressed on the surface of blood cells. These changes will perturb blood cell production and may be able to be targeted effectively with drugs. We will test this using laboratory-based and mouse models of MPN, together with specific drugs that are currently in the clinic, and that inhibit the activity of the key receptors involved. This approach can be rapidly translated to clinical trial.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $607,559.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

mutation analysis | myeloid | myeloid leukaemia | myelopoiesis | receptor tyrosine kinase (RTK)

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