Airway extracellular matrix and smooth muscle in chronic obstructive pulmonary disease (COPD)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1063068

Funding Status
Closed

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Funded Activity Summary

In asthma the layer of airway smooth muscle is thicker, due to more muscle cells. Airway narrowing is excessive but reversible. In chronic obstructive pulmonary disease (due mainly to smoking) the layer of airway smooth muscle is also thicker but the airways cannot be induced to open, or close. Our data suggest that this fixed airway narrowing is likely to be due to an excess of matrix between cells rather than muscle. This project will comprehensively test this new finding.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $828,849.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

airway remodelling | airway smooth muscle | chronic obstructive pulmonary disease (COPD) | extracellular matrix | respiratory diseases

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