Elucidation of the gene regulatory networks that cause Alzheimer's disease in Down Syndrome;

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1062802

Funding Status
Closed

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Funded Activity Summary

People with Down syndrome have an extra chromosome 21 and all develop Alzheimer's disease. We are able to delete different parts of chromosome 21 in Down syndrome stem cells and turn these cells into the two main cell types of the brain. By comparing the occurrence of Alzheimer disease with gene expression changes in these gene-edited cell types we can identify the gene-regulatory pathways that cause Alzheimer's disease in Down syndrome and identify novel therapeutic targets for sporadic Alzheimer's disease.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $782,418.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | Down syndrome | gene regulation | neurodegenerative disorders | neuron-glia interactions | stem cells

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