The L-type calcium channel as a reporter of successful morpholino oligomer therapy in treatment of Duchenne Muscular Dystrophy cardiomyopathy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1062740

Funding Status
Closed

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Funded Activity Summary

Duchenne Muscular Dystrophy is a fatal muscle wasting disorder. We have previously characterised how the heart fails in a mouse model of muscular dystrophy. We now have preliminary data demonstrating that treatment of mice with morpholino oligomers can rescue cardiac function. This project will fully characterise the effect of the treatment on heart function and optimise therapy regimes with the view to utilising the optimised protocol as a guideline in treating cardiomyopathy in Duchenne Muscular Dystrophy boys.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $595,062.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cardiomyopathy | contractility | metabolism | mitochondrial function | muscular dystrophy

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