The role of the asymmetric cell division regulator GPSM2 in mammary gland development and breast cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1062103

Funding Status
Closed

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Funded Activity Summary

Tissues are built by small populations of progenitor cells which divide unequally to generate different cell types. Recent studies suggest defective progenitor cells are founders of some breast cancers and that progenitor-like cancer cells resist therapy to regenerate tumours. We have shown a progenitor division regulator called GPSM2 controls these cells and inhibits breast cancer. Examination of this new anti-tumour pathway promises to identify therapeutic targets for breast cancer recurrence.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $647,539.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

breast cancer | breast development | cancer biology | cell polarity | epithelial biology | epithelial morphogenesis | mouse models | stem cell biology

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